Combine 1 bottle hot pepper sauce, ½ cup butter, Worcestershire sauce, oregano, onion powder and garlic powder in a saucepan over medium heat. Bring mixture to a boil, reduce heat to low and simmer for 5 minutes.
Place chicken wings into slow cooker and pour sauce mixture over wings. Cook on High for 2 hours. Reduce heat to low and cook 2 hours more.
Preheat oven to 400 degrees. Grease several baking sheets. Spread wings onto prepared baking sheets and bake until wings are crisp and browned, about 30 minutes.
Melt ½ cup butter and 1 bottle hot sauce in a small saucepan and simmer until thickened, about 20 minutes. Brush sauce onto wings just before serving.