Preheat oven to 400 degrees. Coat a medium baking dish with non-stick cooking spray.
In a shallow bowl, mix bread crumbs, Parmesan cheese, Romano cheese, garlic powder and salt.
Brush both sides of orange roughy fillets with butter and dredge in the bread crumb mixture. Arrange fillets in a single layer in the prepared baking dish and sprinkle with parsley.
Bake in oven 10 to 15 minutes or until the fish flakes easily with a fork.